In relation to cholesterol metabolism answer the following: A- Explain how cholesterol synthesis depends on the activity of “ATP-citrate lyase” enzyme? B- “3-Hydroxy-3-methylglutaryl CoA” is a common metabolite in two

In relation to cholesterol metabolism answer the following:
A- Explain how cholesterol synthesis depends on the activity of “ATP-citrate lyase” enzyme?

B- “3-Hydroxy-3-methylglutaryl CoA” is a common metabolite in two pathways, mention the names of these two pathways? determine which pathway this metabolite follows?

C- The combination of cholestyramine and an HMG CoA reductase inhibitor is very effective in reducing serum cholesterol for most patients with high cholesterol. Why is this treatment much less effective for patients with Familial hypercholesterolemia?